2008 PBL Cat_mech_r.qxd:PBL Catalog.mech 11/29/07 1:50 PM Page 36
Interferon Receptor Reagents
Interferon Receptors
Antigen Clone Type Catalog # Size
Human IFN-γ R1 n/a Soluble Receptor Chain 1 11580-1 10 µg
Mouse IFN-γ R1 n/a Soluble Receptor Chain 1 12580-1 10 µg
Interferon Receptor Antibodies
Antigen Clone Type Catalog # Size
Human IFN-α/β R1 MMHAR-1 Monoclonal mouse IgG
1
, non-neutralizing 21375-1 500 µg
Human IFN-α/β R2 (IFNAR 2) MMHAR-2 Monoclonal mouse IgG
2A
, neutralizing 21385-1 50 µg
Human IFN-γ R1 MMHGR-1 Monoclonal mouse IgG
1
, non-neutralizing 21580-1 200 µg
Human IFN-γ R2 MMHGR-2 Monoclonal mouse IgG
1
, non-neutralizing 21585-1 250 µg
Human IFN-γ R2 MMHGR-10 Monoclonal mouse IgG, non-neutralizing 21586-1 250 µg
Mouse IFN-γ R1 RMMGR-1 Monoclonal rat IgG, non-neutralizing 22580-1 50 µg
Human IFN-α/β R1 (IFNAR1) n/a Polyclonal goat IgG, non-neutralizing 31375-1 100 µg
Human IFN-α/β R2 (IFNAR 2) n/a Polyclonal rabbit serum, non-neutralizing 31385-1 50 µg
Human IFN-γ R1 n/a Polyclonal rabbit serum, non-neutralizing 31580-1 200 µg
Human IFN-γ R2 n/a Polyclonal rabbit serum, non-neutralizing 31585-1 50 µg
Human IL-10 R2 n/a Polyclonal rabbit serum, non-neutralizing 31852-1 50 µg
Mouse IFN-γ R1 n/a Polyclonal rabbit serum, non-neutralizing 32580-1 50 µg
Mouse IFN-γ R2 n/a Polyclonal rabbit serum, non-neutralizing 32585-1 50 µg
R and RC are synonymous terms for Receptor Chain.
TYPE II INTERFERON RECEPTOR COMPLEX
γ R2 γ R2
γ R1 γ R1
IFNγ
IFNγ
k
2
k
2
k
2 Ja
Ja Ja Ja
k
2
k
1
k
1
k
1 Ja
PP
k
Ja Ja
Ja 1
Tyr457
PP
STAT 1
Nuclear Translocation
This model represents the signal transduction pathway upon the IFN-γ dimer
binding to the two chains of the IFN gamma receptor complex, IFN-γ R1 and IFN-γ
R2. (Type II interferon consists only of IFN-γ).
PBLInterferonSource Toll Free: 1 877- PBL-8881
36
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