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TIVE
Cologne Excellence Cluster:
Cellular Stress Responses in Aging-Associated Diseases
announces 7 faculty positions
Increasing life expectancy is concomitant with increased risk of aging-associated diseases, e.g.
obesity, diabetes, atherosclerosis, cancer, and neurodegenerative diseases, for most of which only
CELLENCE INITIA
unsatisfactory therapies exist. 7o date, unraveling the speci�c, common molecular basis of the aging
process itself and diseases associated with it has proven a formidable task. However, the remarkable
recent discovery that mutations in single genes, such as those in the insulin signal transduction pa-
thway, and those controlling mitochondrial function or synthesis of the membrane lipid ceramide can
extend lifespan has opened new genetic avenues to investigate a broad spectrum of aging-related
damage and pathology. The mission of the Cologne Excellence Cluster on Cellular Stress Responses
in Aging-associated Diseases (CECAD) will be to unravel the common molecular mechanisms un-
derlying lifespan regulation and aging-associated diseases to set the ground to achieve its long-term
objective of developing novel therapeutic interventions. CECAD will be a unique research venture
unifying researchers at the University of Cologne with those at the Max Planck Institute for the Biolo-
gy of Aging. CECAD will be active in four core research areas with a special emphasis on understan-
ding how pathways regulating lifespan interconnect.
TLIGHT ON GERMANY – EX
To further strengthen and complement the joint research program of the
University of Cologne and the newly founded Max-Planck-Institute for the Bio-
SPO
logy of Aging, the Cologne Excellence Cluster CECAD announces 7 faculty
positions ranging from tenure track independent research group leaders
to tenure full professors. Positions include an attractive start-up package and
access to a suite of research facilities. Applicants should have a proven research
track record on molecular mechanisms of cellular stress responses in control of
life span and/or the pathophysiology of aging-associated diseases including, but
not limited to mitochondrial function, ER-stress response, autophagy, in�ammato-
ry and metabolic signaling pathways and those controlling membrane function.
Applicants must include a letter of interest, Overview of CECAD`s 4 core research areas
a curriculum vitae, including publication list, a
Research Area C
statement of research interests, and contact
Obesity
information for at least three references. Appli-
Infection
Research Area B
cations may be sent to CECAD, c/o Prof. Jens
Research Area D
Brüning, Institute for Genetics, Zülpicher Str. 47,
TLR TNF-R
Ceramide
Insulin-R
D-50674 Cologne, Germany. The closing date Research Area A
for applications is December 16, 2007.
IKK
Diabetes
The University of Cologne is an equal ER
Jnk
opportunity employer in compliance with the
IRS
NFc4bB
German disability laws. Women and persons
Obesity ROS
Infection
with disabilities are therefore strongly encoura-
Aging
ged to apply.
Inflammation
Metabolism
Pathogen Defense
Life Span
Atherosclerosis
Cell Proliferation
Malignant Transformation
For detailed information, please visit www.cecad.uni-koeln.de.
7
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ember 200
University of Cologne
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