COLLABORATIVEPROJECTSWITHFEDERAL
INSTITUTES/CENTERS
ClinicalIsletTransplant Registry(NIH) Beta-O2,Inc.,Israel
WithDr.A.Rotemtotest thepotentialuseofimplantable
ClinicalIsletTransplant Consortium(NIH) devicesabletogenerateoxygentoimproveislet
transplantationoutcome.
Islet CellResources(NIH)
General Biotechnology,LCC,Harlan Biotechnology Center,
Indianapolis,IN
JDRF Pancreas Characterization Initiative - nPOD WithDr.E.Woods,ontheeffectsofporcine-derivedsmall
(Network for Pancreatic Organ donors with Diabetes) intestinesubmucosal(SIS)membranesonthefunctionof
Thegoalistoscreendonorpancreata toidentifythose pancreaticislets.
affectedbyautoimmunediabetes,togainaccesstohuman
tissuesfromdiseasedpancreatawithnovelmolecular tools. IsoTherapeutics Group LLC,Angleton,TX
WithDrs.J.SimonandK.Frankonradiation-based
NIH/NIDDKTrialNet imunointerventionsfortoleranceinductioninislet
Aninternational,multicentereffort todevelopandexecute transplant recipients.
clinicaltrialstoprevent andamelioratetype1diabetes.
LifeScan/CENTOCOR - Johnson & Johnson,Radnor,PA
NIH/NIDDKType 1 Diabetes Consortium WithDrs.M.ZimmermanandJ.J.O’Neiltestingnovelapproaches
Aninternationaleffort tostudythegeneticsoftype1diabetes. toimproveislet engraftment andfunctionaftertransplantation.
Maxi-Med,Atlanta,GA
IncollaborationwithMaxi-Medwehavebeenworkingto
COLLABORATIVEPROJECTSWITHINDUSTRY
developandtest acomputerizedalgorithmfordosingapre-meal
insulinbolus.Thetestingphaseofthetechnologywillpossibly
Amylin Pharmaceuticals Inc,San Diego,CA
requirecollaborationwithalargeglucosemetercompany-we
TohelpAmylinPharmaceuticalsunderstandthemolecular
havemadeinitialcontact withJohnsonandJohnson(Lifescan).
pathwaysbywhichsomeoftheirdrugsprotect isletsinthe
transplantationsetting.
Novo Nordisk Pharmaceuticals and Aventis Pharmaceuticals
PracticalToolsforGlycemicControlinType2Diabetes:
BioLife Solutions,Binghamton,NY
Basal/BolusInsulinTherapy.WithDr.ZismanintheDivision
WithDrs.J.Baust andV.Buskirk,extendingtheexvivolifeof
ofEndocrinology,withsupport fromunrestrictededucational
pancreaticisletsandbonemarrowstemcellsinsupport of
grantsfromNovoandAventis,wehavedevelopedand
improvedtransplant methodologies.
implementedaprofessionaleducationinterventiontoupdate
primarycareprovidersontheappropriateuseofnewinsulin
BD Biosciences
analogs.Wearemonitoringtheirprescriptionhabitsandcomfort
Testingnovelplatformstoassessoxygenconsumption
levelpre-andpost-interventiontoassesstheimpact
ratesinisolatedislets.
ofthiseducationeffort.
BD Biosciences
Pharmaceuticaltrialswithvariouscompaniesincluding,but not
Roleofextracellularmatricesonislet potency,survivability
limitedto:GlaxoWellcome,Merck,Bristol-Myers-Squibb,Pfizer,
andproliferationinvitro.
Bayer,Parke-Davis,SKB,etc.
BD Biosciences
Highthroughput analysisofcellularfunction.
BD Biothechnologies,ResearchTriangle Park,NC
Acollaborationwhichisexaminingwhetheraddingextracellular
matrix(ECM)proteinstoisletsinculturewillprotect them.
TheECMaffectsthesurvivalofisletsandthecollaboration
withBDBiotechnologiesfocusesonthebenefit ofreconstructing
anECMthat mimicsthenaturalsettingfortheisletsprior
totransplantation.
2007annualreport 75
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