COLLABORATIVEPROJECTSWITHUNITEDSTATES
ACADEMICANDRESEARCHINSTITUTIONS
Barbara Davis Center for Childhood Diabetes, Memorial Sloan Kettering Cancer Center
University of Colorado WithDr.M.CurranintheDepartment ofGeneTherapyin
WithDr.J,Hutton,studiesonthethymicexpressionofa generatingandtestingcombinationsofanti-apoptoticgenes
noveldiabetesautoantigen,IGRP. inFelineImmunodeficiencyVirusforprotectionof
transplantedislets.
Benaroya Research Institute,Seattle,WA
WithDr.J.NepomandH.Reijonen,wearecollaboratingon National Institutes of Health Laboratory of Viral Diseases,
thestudyofautoreactiveTcellsintransplant recipients Bethesda,MD
usingtetramertechnology. WithDr.B.Moss,ontheroleofIL-18bindingproteinin
humanTcellregulation.
Boston University School of Medicine,Boston,Mass
WithK.Tornheimonpancreaticß-cellmetabolism North Shore University Hospital,Syosset,NY
WithDr.S.Goyert,acollaborationhasbeenrecentlyestablished
Columbia University,NY toutilizeastrainofmicegeneticallymanipulatedtoknockout
WithDrs.A.M.Schmidt andK.Heroldtostudytheeffects theCD14genetoanalyzeitsroleonislet cellsurvival.
ofRAGEinhibitorsonenhancement ofislet engraftment in
anonhumanprimatemodel. Rogosin Institute,Xenia,OH
WithDr.Gazdaonislet immmunoisolationandencapsulation.
Emory University School of Medicine
WithDr.P.Thule,thegenerationofself-complementary Stanford University,Stanford,CA
AAVforthetransductionofislets. WithDr.G.NolanintheDepartment ofMolecularPharmacology,
testingofanti-apoptoticgenesclonedintoFeline
Emory University School of Medicine ImmunodeficiencyVirusforprotectionoftransplantedislets.
IncollaborationwithDrs.A.Zisman,L.Prieto-Sanchezand
G.Umpierrez(EmoryUniversity)weareconductinga two-site State University of New York (SUNY) at Binghamton
in-patient studytoevaluatebasal/bolusinsulintherapy (and BioLife Solutions),Albany,NY
comparedtoconventionalinsulinmanagement.Resultsofthis WithDr.J.Baust,evaluationofroleofnovelpreservation
project shouldhelpusbetterdefineinsulinmanagement solutionsforpancreasandislet transplantationandshipment.
strategiesforthehospitalizedpatient.
Temple University,Philadelphia,PA
Emory University School of Medicine WithDr.C.Platsoukas,immunopathogenesisofchronicrejection.
WithDrs.C.WeberandS.Safleyonstrategiesforislets
immmunoisolationandencapsulation. University of Florida,Gainesville,FL
JDFIGeneTherapyCenterforthePreventionofDiabetesand
Harvard Medical School,The Center for Blood Research DiabeticComplicationsat theU.ofMiamiandU.ofFloridawith
WithDr.Z.AwdehandC.Alperstudiesabout thegenetics Drs.T.Flotte,M.A.Atkinson,A.AgarwalandH.Nick,toassess
oftype1diabetes. theeffectivenessofselectedanti-apoptoticgenesinadeno-
associatedvirustoprevent orreducecytokine-inducedapoptosis
Massachusetts General Hospital,Boston,MA inmurinepancreaticisletsinvitroandinvivo.
WithDr.M.Freeman,identificationofcandidategenes/
proteinsinvolvedinintracellularcholesteroltransport leading University of Florida,Gainesville,FL
toremovalofexcesscellularcholesterolfromcellsinvolvedin WithDrs.M.A.AtkinsonandS.Songontheeffectsofalpha-1
atherosclerosis. anti-trypsinonautoimmunityandislet transplantation
immunobiology.
Massachusetts Institute ofTechnology (MIT),Cambridge,MA
WithDr.H.Lodish,theuseoferythropoietintoprotect islets University of Florida,Gainesville,FL
fromapoptosis. WithDr.FlottestudyingtheuseofanAAVvectorwithaTER
repressortoconditionallyexpressprotectivegenesinislets.
Memorial Sloan-Kettering Cancer Center,New York,NY
WithDr.M.Moore,functionalcharacterizationofstemcell University of Illinois at Chicago,Chicago,IL
content ofCD34+cellsharvestedfromcadavermarrowusing WithDr.A.BartholomewfromUniversityofChicago;NIAID
different separationmethods. programproject forstudyoftheroleofhematopoieticand
mesenchymalstemcellsintoleranceinductioninNHPmodels
ofrenalandislet allotransplantation.
72 DIABETES RESEARCH INSTITUTE
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