University of Iowa Hospitals and Clinics,Iowa City,Iowa DIBIT,Human Immunology Unit,Milan,Italy
WithP.Giangrandeontreatment ofGVHDandautoimmunity WithDr.R.Pardi,theuseofnovelimmunomodulatorytherapies
usingaptamer-targetedsiRNAtoeliminateautoreactiveTcells. inpreventionofislet cellrejection.
University of Pittsburgh School of Medicine,Pittsburgh PA Ecole polytechnique Fédérale de Lausanne,Institut de Science
WithDr.A.F.Stewart,studiesongenemodificationofpancreatic Biomoléculaire,Switzerlandz
isletsforenhancement ofpost-transplant survivalin Dr.H.Vogel,imagingoftheendocrinepancreas.
nonhumanprimates.
European Institute of Oncology,Division of Nuclear
University of Rochester School of Medicine,Rochester,NY Medicine,Milan,Italy
H.J.Federofffortestinganti-apoptoticgenesclonesinto WithDr.G.Paganelli,definingnovelstrategiesof
HerpesSimplexVirusforprotectionoftransplantedislets. immunosuppression/myeloablationbasedonaunique
techniquedevelopedbyDr.Paganellithat takesadvantage
University ofTennessee,Knoxville,TN oftheuseofdirectedradiotherapy.
T.Hughes,ontheRetirement ResearchFoundationgrant in
HDLsubfractionation. Fujian Medical University,Fuzhou General Hospital,
Fuzhou,China
University ofTexas Health Science Center,San Antonio,TX WithDrs.J.Tan,E.Estrada(Argentina),C.LucenaandE.Lucena
WithDr.F.Follitoperformproteinprofilingandstudyingcyclin (Colombia)tostudythesafetyandefficacyofthecombined
expressioninisolatedhumanislets. therapyofhyperbaricoxygentherapyandautologousbone
marrowstemcellinfusiontotreat diabetes.
University of Virginia,Charlottesville,VA
WithDr.J.L.Nadlerontheuseofnewanti-inflammatory Geneva University Hospitals,Geneva,Switzerland
(Lisofylline)agentstoimproveislet engraftment. WithDr.T.BerneyonMolecularmonitoringoftheislet graft
andIslet ofLangerhansimaging.
University ofWashington,Seattle,WA
WithDr.J.Oram,identificationofmembranelipidmicrodomains Grenoble Medical University,LaTronche Cedex,France
involvedinhigh-densitylipoprotein-mediatedremovalofexcess WithDr.P.Chaffanjononprospect forthebest transplantation
cellularcholesterol. siteforpancreaticislets:validationofanomentalflapsitein
largemammal.
Vanderbilt University,Nashville,TN
WithDr.M.Magnuson,toproducespecificinsulin Hospital de Clínicas FCM- UNA (Paraguay)
receptorknock-out mice. IncollaborationwithDr.A.Benitez,ondefiningdiabetesand
cardiovascularriskstatusinindigenouspopulationsofParaguay.
Wake Forest University,Winston Salem,NC
WithDr.A.Atalatoassesstheviability,cellularcompositionand Institute of Physiology,Maribor,Slovenia
function(in-vitroandin-vivo)ofinsulin-producingcellsderived WithM.Rupnikonmeasurementsofpancreaticß-cellelectrical
fromamnioticstemcells. activityandexocytosisundermoreinvivolikeconditions.
Whittier Institute,La Jolla,CA Institutet de Science Biomoléculaire Lausanne,Switzerland
WithDrs.V.CirulliandA.Hayekonß-cellreplicationand WithDr.H.Vogelontheuseofbioprobesforstudiesof
neogenesisfromductalpancreaticstemcells. pancreaticß-cellsignaltransduction.
Istituto Mediterraneo per ITrapianti eTerapie ad alta
Specializzazione – DRI-ISMETT
COLLABORATIVEPROJECTSWITHINTERNATIONAL WithDrs.B.GridelliandF.Bertuzzi;Testingtheuseofhyperbaric
ACADEMICANDRESEARCHINSTITUTIONS
oxygentherapyandautologousstemcellstopromoteislet
regenerationandenhancethemassofinsulin-producingcells
Centre for Addiction and Mental Health,Toronto,ON,Canada
aftertransplantationandpromotelongtermsurvival.
WithDr.A.Petronistostudyepigeneticmodificationsthat may
altertheexpressionoftheinsulingeneinthethymus,whichis
Johannes Gutenberg University Mainz,Mainz,Germany
criticaltoself-toleranceandsusceptibilitytotype1diabetes.
WithDr.T.Hankelntostudyprotectionofisletsthrough
ChaimShebaMedicalCenter,Tel-Hashomer,Israel:withDr.S.
transductionofNeuroglobin,anoveloxygenbindingprotein.
Ferber,onthetransdifferentiationofhepaticcellsintoinsulin-
producingcells.
2007annualreport 73
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