DiabetesResearchInstitute Thecentersareconcentratingcollectively Islet IsolationMethod”usesorgans
Federation
oncuringdiabetesthroughtolerance fromnonheart-beatingdonorsthat
In2006,theDRIexpandedthisideaof
induction;transplantationofisletsand werepreviouslyrejectedfortransplant
collaborationwellbeyonditswallsina
otherinsulin-producingcells;stemcell useduetotheirpoorquality.TheKyoto
trueinternationalframeworkthrough
therapies;andregenerativemedicine researchersalsoareexploringother
theformationoftheDiabetesResearch
strategiesusinganintegrated, techniquestoincreaseislet supplyand
InstituteFederation.TheDRIFederation
translationalapproach. obtainthehighest islet yields.
isapartnershipamongleadingscientists
fromselecteddiabetesresearch
Approvedstudiesfocusonanyof11 OtherFederationteamsarefocusing
institutionsfromaroundtheworld.The
researchareasofanaggressiveplan onstemcellresearch;theregeneration
missionoftheDRIFederationissimple–
developedtofindacurefortype1 ofislets;approachestoachievedonor-
tofindacurefortype1diabetesthrough
diabetes.Thisplanissimilartothe specifictolerance;andotheremerging
aninternational,cooperativeeffort by
project-orientedmodelcurrentlyused technologies.Onesuchresearchpartner
exploitingtheknowledgeandresources
internallybytheDRIthat hasbeen isHelenaEdlund,Ph.D.,theDanielH.
ofeachparticipant.
successfulinbringingnewtechnologies MintzVisitingProfessorandDirectorof
andtherapiestotheclinicalarena. PancreaticDevelopment andProgenitor
JoiningtheDRIFederation
CellBiologyat theDRI.Shealsoisa
arescientistsfromthefollowing
Drawingupontheexpertiseofthe ProfessorofMolecularDevelopmental
researchprograms:
individualparticipants,theinfrastructure Biologyat UmeaUniversityinUmea,
oftheDRIFederationwillenableeach Sweden.Dr.Edlund'sworkisconcentrated
researchcenter toconcentrateonone,or onidentifyingthecriticalfactorsthat
• UniversityofMiamiinMiami,Florida
more,particulararea,suchas“Tolerance” definethedevelopment ofinsulin-
• UniversityofAlbertain
or“NewSourcesofInsulin-producing producingvs.noninsulin-producingcells
Edmonton,Canada
Cells,”whileenjoyingthecollaborative ofthepancreas,withspecialemphasis
• HospitalSanRaffaeleinMilan,Italy
support ofpeersfromother onthedevelopment ofß-cells.
• MediterraneanInstitutefor
participatingprograms.
TransplantationandAdvanced
SpecializedTherapies(ISMETT)in
ClinicalIsletTransplant
Forexample,developingnewsources
Palermo,Italy
Consortium
ofislet cellsremainsakeyconcern
• HospitalUniversitariBellvitge-Islet
forscientists.TheDRI,incollaboration
InadditiontoformingtheDRIFederation,
TransplantationUnit (UTIP-HUB)
withscientistsfromtheIsraeliprogram
theDRIisalsoakeyplayerintheClinical
inBarcelona,Spain
D-Cure,iscurrentlyattemptingto
IsletTransplantationConsortium(CITC),
• KarolinskaInstitutet in
engineerandcharacterizenovelsources
whichwasestablishedin2004.This
Stockholm,Sweden
ofinsulin-producingcells.Ifresistant to
consortiumisanetworkofclinicalcenters
• UmeaUniversityinUmea,Sweden
autoimmunity,thesecellsmayhavegreat
andadatacoordinatingcentercreatedto
• KyotoUniversityinKyoto,Japan
potentialforclinicaltransplantationand
conduct studiesofislet transplantations
• D-CureinTelAviv,Israel
mayeliminatetheproblemofscarce
inpatientswithtype1diabetes.
• UniversityofOxfordinOxford,UK
donoravailability.
• UniversityofGenevain
Geneva,Switzerland
Toaddresstheissueofdonorshortages
• UniversidaddeSãoPauloin
fromanotherangle,theteamfromKyoto
SãoPaulo,Brazil
Universityhasbeenworkingtooptimize
proceduresforisolatingislet cellsfrom
marginaldonorpancreases.The“Kyoto
2007annualreport 65
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