CordBloodCells Asthesecellshaveprovencapableof Dr.Atalaandhisteamdemonstrated
TheDRIhasalsoestablishedanew
reconstitutingthebonemarrow,it is that specificpopulationsofcellswithin
programtoactivelyexploretheuseof
possiblethat theycanbeconverted theamnioticfluidcouldbeexpanded
umbilicalcordbloodcellsasasourcefor
intoisletstoreplacethoselost intype1 indefinitelyandalsoretainamuch
islets.Theumbilicalcord,obtainedfrom
diabetes.Also,theycouldbeusedto higher-than-expectedflexibility.
anewborn,isveryrichinhematopoietic
re-educatetheimmunesystemofthe Thesecellswereeducatedtodifferentiate
stemcells.Theseblood-derivedstemcells
recipient,establishingastateof alongthethreemajorpathwaysof
aremostlyfoundinthebonemarrowand
immunetolerance. development –endoderm,ectodermand
areknowntogiverisetoallofthecell
mesoderm–whichisamajorcapability
typesoftheblood,includingtheredblood
ofembryonicstem(ES)cells.
AmnioticStemCells
cellsandtheentireimmunesystem.For
thisreason,theyhavebeenusedsincethe
Amnioticfluidrepresentsanother
early1990sfortransplantationinblood-
potentialsourceofinsulin-producing
TogetherwithDr.Atala,theDRIPancreatic
relateddiseases,suchasleukemia.
tissue.Theamnioticfluidsurroundsthe
StemCellandTissueEngineeringteams
fetusuntilbirthandisrichinfree-floating
arepursuingthisimportant workto
fetal–cellsoftenusedforprenatal
obtainaplentifulsourceofinsulin-
Smallsubsetsofhematopoieticcellsare geneticscreening(amniocentesis).In
producingcells.
multipotent,whichmeanstheycangive 2006,theDRIteamedwithDr.Anthony
risenot onlytothebloodandimmune AtalaofWakeForest University toexplore
system,but alsotoothercelltypes,such newstemcelltherapies,includingthe
asbone,cartilageandfat.Morerecently, potentialofamniotic-stem-cell-derived
researchershavefoundevidencethat insulin-producingcells.
select populationsofcellswithinthebone
marrowandcordbloodmaybecome,
underverydefinedconditions,manyother
tissues–includingpancreaticß-cells.
34 DIABETES RESEARCH INSTITUTE
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