final thought
Dose of stanol/sterol (grams per day)
4.0
1 0.8 - 1.1 1.5 -1.7 1.8 -2.0 2.1 - 2.4 > 2.5
)
-1 3.5
e
r
ol (%
-3
l
e
s
t
r
o
l (mmol/l)
3.0
-5
e
s
t
e
-7
- 5.9
- 5.5
- 6.1
2.5
- 7.6
-9
- 8.5
- 8.0 LDL chol
2.0
- 9.4
-11
Reduction in LDL cho
- 10.6
- 11.6
1.5
-13 - 12.2
Control Once Three times
sterol stanol
per day per day
Timing of Dosage containing plant stanol esters is continuing — from the widely avail-
Most studies on stanol consumption have evaluated the effects of able low fat spreads to yoghurt drinks, cooking oils and other means
stanol esters divided into two or more doses. However, a study of of delivery.
a single intake of 2.5 g per day, ingested during the midday meal,
was as effective at lowering serum LDL cholesterol concentrations as
when the dosage was divided between three meals and was propor-
tional to the dietary cholesterol intake (Figure 2).
3

Timing and Method
In conclusion, it has been demonstrated that the efficacy of plant
stanol esters is highest when consumed as part of a meal, and is
compromised when taken on an empty stomach. An optimum dose
at a relatively low level (approximately 2 g per day) provides maxi-
mum effect, and can be taken once a day with a meal.
Different food products do seem to influence the efficacy of plant
stanol esters, but even more influence may be the acceptability of References
the foodstuff to the consumer. As a result, the development of foods 1. For a full list of clinical references, please refer to Raisio Benecol Ltd.
2. R.P. Mensink, et al., “Effects of Plant Stanol Esters Supplied in Low Fat
Yoghurt on Serum Lipids and Lipoproteins, Non-Cholesterol Sterols and
Fat Soluble Antioxidant Concentrations,” Atherosclerosis 160,
205–213 (2002).
3. J. Plat, et al., “Effects on Serum Lipids, Lipoproteins and Fat Soluble
Antioxidant Concentrations of Consumption Frequency of Margarines and
Shortenings Enriched with Plant Stanol Esters,” Eur. J. Clin. Nutr. 54,
671–677 (2000).
For more information
Titta Ezra, VP Marketing,
Raisio Benecol Ltd,
PO Box 101 (Raisionkaari 55), FI-21201 Raisio, Finland.
Tel. +358 2 443 2455
titta.ezra@raisio.com
www.nutraceuticalmag.com may digital 2007 nutraceutical business & technology 35
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